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5.1. Make a diagnosis and thus know the natural history



5.1.1. Acute Disease

Ill (very ill) Baby or Child – Fever, Malaise, Septicaemia

Pain in Limb or Joint

Not using Limb (pseudo-paralysis)

Swelling of limb/s or joint/s (Note sympathetic joint effusions may occur with osteomyelitis in their vicinity, e.g. in the knee when the distal end of the femur is involved)

Localised tenderness

Pain on attempted joint movement

Note, all of these symptoms and signs may be modified or reduced if antibiotics have already been given.

5.1.2. Radiology

There will be NO RADIOLOGICAL CHANGES for a minimum of ten days with acute osteomyelitis, and therefore NORMAL RADIOGRAPHS do not rule out a clinical diagnosis of severe bone or joint infection. In fact radiographic changes may not appear for three weeks or more, and can range from very minor with minimal bone destruction and a little sub-periosteal bone formation, to evidence of much more severe bone destruction (moth-, or rat-eaten bones).

There may be soft tissue swelling and obliteration of fat planes.

A joint (particularly the hip) may be dislocated – as a result of the presence of a large collection of pus in the synovial cavity which has stretched the capsule.

Septic arthritis of an infant's hip with dislocation and enormous swelling of the thigh.

5.1.3. Laboratory investigations

There is likely to be a raised Sedimentation Rate (ESR), and a raised White Cell Count. In a non immuno-suppressed patient a pyogenic infection will result in a marked increase of neutrophils. In immune suppression, e.g. HIV/Aids this may be absent.

Pus for Gram Staining and Culture, and Blood for Culture (and if possible for Sensitivity Testing) should always be taken, and when possible this should be done before antibiotics are given. But antibiotics should be given empirically as soon as blood has been taken for culture. They can be changed if this is suggested when sensitivity results become available (usually 48 hours).